Penicillin resistance in Enterococcus faecalis: molecular determinants and epidemiology

Iwona Gawryszewska, Waleria Hryniewicz , Ewa Sadowy
Pol J Microbiol
2012; 61 (3):
ICID: 1014502
Article type: Original article
IC™ Value: 10.00
Abstract provided by Publisher
 
Enterococcus faecalis plays a significant role in hospital-acquired infections (HAIs), and combination of penicillin with aminoglycoside is important in therapy of invasive HAIs. Penicillin resistance in this organism is due to modification of the drug target, penicillin-binding protein (PBP5), its overproduction and expression of -lactamase. Although rare, this phenotype is often associated with multi-resistant high-risk enterococcal clonal complexes (HiRECCs), such as CC2 and CC9 which may promote its spread in the near future.
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