The capacity of Mycobacterium complex species and M. bovis BCG substrains specific identification – implications for optimized PCR-based diagnosticsin adverse events following vaccination suspected cases
Katarzyna Krysztopa-Grzybowska, Sylwia Brzezińska, Ewa Augustynowicz-Kopeć, Zofia Zwolska, Ewa Augustynowicz, Anna Lutyńska Pol J Microbiol 2012; 61 (4): ICID: 1031328 Article type: Original article IC™ Value: 10.00
Abstract provided by Publisher
Three nucleic acid techniques approaches described in the literature as potentially applicable in the diagnostics were tested for its capacity of differentiation of Mycobacterium bovis BCG from other members of M. tuberculosis complex species in samples of mycobacteria grown from individuals suspected of adverse events following BCG vaccination comparing to appropriate reference strains. The goal of this pilot study was the evaluation of their identification capacity for routine confirmation of the mycobacteria species as infection source in the cases of adverse events following BCG vaccination.