Lack of association between Helicobacter pylori infection and billary tract diseases
Somayeh Jahani Sherafat, Elahe Tajeddin, Mohammad Reza Seyyed Majidi, Farzam Vaziri, Masoud Alebouyeh, Amir Hooshang Mohammad Alizadeh, Ehsan Nazemalhosseini mojarad, Mohammad Reza Zali Pol J Microbiol 2012; 61 (4): ICID: 1031330 Article type: Short communication IC™ Value: 6.00
Abstract provided by Publisher
There are ambiguous results about involvement of H. pylori in hepatobiliary diseases. H. pylori DNA was detected in human liver tissue samples of patients with primary sclerosing cholangitis and primary biliary cirrhosis. We investigated any possible association of Helicobacter species in occurrence of biliary diseases among different patients. Cultures of the bile samples for Helicobacter sp. did not show any growth for the bacterium, but Helicobacter sp. specific PCR was positive in 4 cases of them (3.92%). No significant association was detected between the type of the diseases (gall stone, hepatobiliary cancer, and other biliary diseases) and presence of the bacterium. All the positive DNA samples were belonged to H. pylori species and show vacA+(s1/m1), cagA- genotypes.