Faecalibacterium prausnitzii and Crohn’s disease – is there any connection?

Mirosława Gałęcka, Patrycja Szachta, Anna Bartnicka, Liliana Łykowska-Szuber , Piotr Eder, Andreas Schwiertz
Pol J Microbiol
2013; 62 (1):
ICID: 1039014
Article type: Original article
IC™ Value: 10.00
Abstract provided by Publisher
Purpose: Evaluation of a correlation between the level of clinical activity of Crohn's disease (CD) and the amount of Faecalibacterium prausnitzii, total number of bacteria and the concentration of selected short chain fatty acids (SCFA) in stool.
Materials and Methods: Thirty four individuals diagnosed with Crohn's disease, hospitalized in the Department of Gastroenterology, Nutrition and Internal Diseases, at the University of Medical Sciences in Poznan, Poland in 2011 participated in the study. The disease activity was determined according to the Crohn Disease Activity Index (CDAI). The number of Faecalibacterium prausnitzii, total number of bacteria and concentration of butyrate, acetate and propionate was evaluated in each patient. The amount of Faecalibacterium prausnitzii and total number of bacteria were monitored by real-time polymerase chain reaction analysis. The concentration of mentioned SCFA were analyzed by gas chromatograph.
Results: In patients with CD the number of Faecalibacterium prausnitzii and the percentage of Faecalibacterium prausnitzii of the total amount of bacteria was highly reduced. In all stages of disease activity the total number of bacteria in the feces did not reach the required physiological norm. In patients with CD the percentage of acetate was elevated (70%) while the amount of propionate and butyrate was significantly reduced (14.9% and 7.99%).
Conclusions: The intestinal microbiota in patients with Crohn’s disease (CD) is characterized by decreased numbers of Faecalibacterium prausnitzii and total number of bacteria. The individuals with CD are also characterized by a decrease in the concentration of butyrate and propionate.

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