Tigecycline Susceptibility in Multidrug Resistant Acinetobacter isolates from Turkey

Fethiye F Yılmaz, Hüseyin Taşlı, Süreyya Gül-Yurtsever, Ayça Büyük, Mine Hoşgör-Limoncu
Pol J Microbiol
2013; 62 (3):
ICID: 1072795
Article type: Original article
IC™ Value: 10.00
Abstract provided by Publisher
 
<span lang="EN-US" style="font-size: 12pt;">Acinetobacter</span><span lang="EN-US" style="font-size: 12pt;"> causes respiratory and urinary tract infection, meningitis, endocarditis, burn infections and wound sepsis, especially in intensive care units. Tigecycline, a new semisynthetic derivative of tetracycline, is the first in the class of glycylcycline antibiotics and have an important role in the treatment of nosocomial infections with multidrug resistant (MDR) Acinetobacter isolates. The present study aimed to evaluate antimicrobial activity of tigecycline against 84 MDR Acinetobacter spp. strains isolated several clinical samples by disc diffusion and E-test methods. In addition,<span style="color:red"> </span>two different interpretation ways of the results of disc diffusion test of Acinetobacter isolates were compared. And also, the E-test results and the disc diffusion results that interpreted by both the methods were checked for compatibility. According to the disc diffusion test, 3 strains (3.57 %) were found resistant to tigecycline when considering breakpoints suggested by Food and Drug Administration (FDA). On the other hand, none of the strains was found resistant to the evaluation criteria recommended by Jones et al. (2007). Considering E-test results of tigecycline, MIC50 and MIC90 values of tigecycline for Acinetobacter spp. were 0.75 and 1 mg/l, respectively. Based on FDA defined breakpoints for Enterobacteriaceae, any resistant isolate was detected. In conclusion, although there are some differences in the results, tigecycline was found quite effective on Acinetobacter spp. isolates with reference to the both disc diffusion and the E-test methods.</span>
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