Cellulase inhibits Burkholderia cepacia biofilms on diverse prosthetic materials

RAJASEKHARAN SATISH KUMAR, SAMIRAJ RAMESH
Pol J Microbiol
2013; 62 (3):
ICID: 1072801
Article type: Short communication
IC™ Value: 6.00
Abstract provided by Publisher
 
Burkholderia cepacia is an opportunistic pathogen causing infections in patients with cystic fibrosis. Patients with implanted devices are prone to the infections of B. cepacia due to its ability to grow as biofilms. Knowing the importance of polysaccharides in biofilm, enzymes that degrade them were targeted as a possible candidate for antibiofilm agents.  In this study, antibiofilm potential of cellulase against B. cepacia biofilms formed on various prosthetic materials was tested. Cellulase exhibited significant antibiofilm activity against B. cepacia without having no much action on its growth thus, ruling out the chance of selection pressure and subsequent development resistance. 
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