Biological evaluation of quaternary bis ammonium salt and cetylpyridinum bromide against S. epidermidis biofilm 

Joanna Stefańska, Anna Pietruczuk-Padzik, Marta Struga, Maciej Borkowski, Stefan Tyski
Pol J Microbiol
2013; 62 (4):
ICID: 1087837
Article type: Original article
IC™ Value: 10.00
Abstract provided by Publisher
Quaternary ammonium compounds are broad-spectrum bactericides widely used as antiseptics, disinfection and preservation agents. The aim of this study was to examine the activity of two quaternary ammonium salts,  cetylpyridinum bromide and a newly synthesized quaternary bis ammonium salt, against S. epidermidis biofilm. The average values of killing efficiency for cetylpyridinum bromide ranged from 26.6% to 64.1% for all tested concentrations (0.125 to 8.0 µg×mL-1) and for quaternary bis ammonium salt the percentage of killing efficiency ranged from 59.7% to 88.4% for tested concentrations (from 2.0 to 128.0 µg×mL-1). Both tested compounds significantly affect on staphylococcal biofilms, but any of used concentrations caused a total eradication of bacterial biofilm.

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