Alternative Genotyping of Drug-Resistant Mycobacterium tuberculosis Strains

Petro B. Antonenko, Valentin I. Kresyun, Kate O. Antonenko
Pol J Microbiol
2014; 63 (2):
ICID: 1115562
Article type: Short communication
IC™ Value: 6.00
Abstract provided by Publisher
 
The aim of the present research was to study the capability of a genotyping method for M. tuberculosis through detection of six VNTR-loci (MIRU10, MIRU26, MIRU31, MIRU39, MIRU40, ETR-A). Loci MIRU10, MIRU26, MIRU40 and ETR-A have exhibited high polymorphism in group non-Beijing, while loci MIRU26 and MIRU31 – in the Beijing family. A combined detec-tion of all six loci for fingerprinting of the isolates both from Beijing and non-Beijing was highly effective (Hunter-Gaston index was 0.88 and 0.93 correspondently), especially in areas with li-mited financial resources and high prevalence of multidrug resistant M.tuberculosis strains.
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