Antibacterial properties of substituted quino[3,2-b]benzo[1,4]thiazines

Anna Czarny, Ewa Zaczyńska, Małgorzata Jeleń, Michał Zimecki, Krystian Pluta, Beata Morak-Młodawska, Jolanta Artym, Maja Kocięba
Pol J Microbiol
2014; 63 (3):
ICID: 1122692
Article type: Original article
IC™ Value: 10.00
Abstract provided by Publisher
Our previous studies demonstrated that among phenothiazines several derivatives could be found showing strong antiproliferative actions and the property of inhibiting inducible tumor necrosis factor alpha (TNF α) production in human blood cultures. The aim of this investigation was to determine potential antimicrobial actions of forty four new phenothiazine derivatives with the quinobenzothiazine structure. The compounds showed differential antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans depending on the compound structures, concentrations and bacterial strains. More specifically, 6-(1-methyl-2-piperidylethyl) quinobenzothiazine displayed strongest actions against S. aureus and E. coli whereas 6-methanesulfonylaminobutyl-9-methylthioquinobenzothiazine exhibited the most universal antimicrobial properties. The correlation between antimicrobial activity and the chemical structure of quinobenzothiazines was discussed.

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