Virus Like Particles as Immunogens and Universal Nanocarriers

Antonina Naskalska, Krzysztof Pyrć
Pol J Microbiol
2015; 64 (1):
ICID: 1148769
Article type: Review article
IC™ Value: 8.00
Abstract provided by Publisher
Over the last two decades virus-like particles (VLPs) have become an important tool in biomedical research and medicine. VLPs are multiprotein structures that resemble viable virus particles in conformation but lack the viral genome. Consequently, they are non infectious and non replicative, but retain the ability to penetrate cells, making them useful for a vast spectrum of applications. Above all, VLPs mimicking genuine viruses in antigenic structure provide a safe alternative to attenuated and inactivated viruses in vaccine development. Moreover, due to their transducing proprieties, VLPs may efficiently deliver foreign nucleic acids, proteins, or conjugated compounds to the organism, or even to specific cell types. Additionally, VLPs are versatile nanovectors due to their flexibility in terms of composition and expression systems.
In this review, different approaches for of virus-like particle synthesis and manipulation, as well as their potential applications, will be discussed.

Related articles in IndexCopernicus™
     virus like particles (VLPs) [0 related records]
     Vaccines [107 related records]
     delivery platform [0 related records]