In Vitro Studies of Antibacterial and Antifungal Wound Dressings Comprising H2TiO3 and SiO2 Nanoparticles
Lukasz Krokowicz, Hanna Tomczak, Adam Bobkiewicz, Jacek Mackiewicz, Ryszard Marciniak, Michal Drews, Tomasz Banasiewicz Pol J Microbiol 2015; 64 (2): ICID: 1160944 Article type: Original article IC™ Value: 10.00
Abstract provided by Publisher
The incidence rate of the infected and complex wound is established approximately 40 000/1 million of the world’s adult population. The aim of this study was to assess the efficiency of three novel types of wound dressings comprising sodium chloride, metatitanic acid and silicon dioxide nanoparticles. The study design was to prove their antimicrobial properties against the microorganisms most commonly causing wound infection. The study evaluated the antimicrobial effect of tested dressings on referenced strains of bacteria (ATCC collection, Argenta, Poland) and strains of fungi species (our own collection of fungi cultured from the patients). The dressings were tested with both bacterial and fungal strains on solid media (Mueller-Hinton, Sobouraud, bioMerieux, France) in the standard method. The results confirmed the inhibition of growth of bacteria and revealed zones of inhibition for Escherichia coli, Staphylococcus aureus and Enterococcus faecalis. Significant zones of inhibition were established for Staphylococcus aureus and for fungi species of the Candida species. These results would be a crucial due to the fact of low availability of antifungal therapeutics for both systemic and topical usage. Moreover, current standard of antifungal treatment is associated with high costs and high toxicity in general. The preliminary results are very promising but further studies are necessitated. According to achieved results, tested dressings may contribute to develop the surgical armamentarium of complex wound management in the near future.