Epidemiological Analysis of Mycobacterium tuberculosis Strains Isolated from Patients of Small Communities Living in the South-East of Poland
Anna Zaczek, Iwona Szwaja, Monika Skiba, Anna Brzostek, Czeslaw Puchalski, Karolina Lewandowska, Jaroslaw Dziadek Pol J Microbiol 2015; 64 (3): ICID: 1170469 Article type: Short communication IC™ Value: 6.00
Abstract provided by Publisher
The diversity of Mycobacterium tuberculosis clinical isolates, collected from a single hospital, was analyzed by ligation-mediated PCR techniques: FLiP and FLAP, and hybridization technique, IS6110-RFLP. Isolated strains were divided in terms of location (3 towns of Podkarpackie voivodeship differing in population size) and relationship (8 members of 4 families, each represented by 2 patients). Within each family identical DNA profiles, as well as drug resistance patterns were identified indicating a great chance of transmission of strains within the same family. The identical, or very similar patterns were also shared by strains isolated from unrelated patients living in a very small town (1 200 inhabitants) or hospitalized in the same place and time.