The probable interspecies transfer of the blaVIM-4 gene between Enterobacter cloacae and Klebsiella pneumoniae in a single infant patient
Katarzyna Piekarska, Katarzyna Zacharczuk, Magdalena Rzeczkowska, Tomasz Wołkowicz, Aleksandra Januszkiewicz, Edyta Podsiadły, Urszula Demkow, Rafał Gierczyński Pol J Microbiol 2015; 64 (4): ICID: 1185239 Article type: Short communication IC™ Value: 6.00
Abstract provided by Publisher
We report interspecies transfer of the blaVIM-4 gene in MBL-producing Enterobacter cloacae and Klebsiella pneumoniae isolates from a newborn patient who had received meropenem therapy. We show the evidence that blaVIM-4 gene was transmitted as a part of the class 1 integron on a conjugative plasmid ca. ~90 kb. High homology of nucleotide sequence was observed between the integron found in VIM-4 producing E. cloacae and K. pneumoniae strains tested and class 1 integrons previously reported in Pseudomonas aeruginosa from Hungary and Poland. This finding may suggest P. aeruginosa as a potential source of the acquired VIM-4 in Enterobacteriaceae.