The probable interspecies transfer of the blaVIM-4 gene between Enterobacter cloacae and Klebsiella pneumoniae in a single infant patient

Katarzyna Piekarska, Katarzyna Zacharczuk, Magdalena Rzeczkowska, Tomasz Wołkowicz, Aleksandra Januszkiewicz, Edyta Podsiadły, Urszula Demkow, Rafał Gierczyński
Pol J Microbiol
2015; 64 (4):
ICID: 1185239
Article type: Short communication
IC™ Value: 6.00
Abstract provided by Publisher
 
We report interspecies transfer of the blaVIM-4 gene in MBL-producing Enterobacter cloacae and Klebsiella pneumoniae isolates from a newborn patient who had received meropenem therapy. We show the evidence that blaVIM-4 gene was transmitted as a part of the class 1 integron on a conjugative plasmid ca. ~90 kb. High homology of nucleotide sequence was observed between the integron found in VIM-4 producing E. cloacae and K. pneumoniae strains tested and class 1 integrons previously reported in Pseudomonas aeruginosa from Hungary and Poland. This finding may suggest P. aeruginosa as a potential source of the acquired VIM-4 in Enterobacteriaceae.
DOI: 10.5604/17331331.1185239
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