Drug resistance and population structure of Mycobacterium tuberculosis Beijing strains isolated in Poland

Monika Kozińska, Ewa Augustynowicz-Kopeć
Pol J Microbiol
2015; 64 (4):
ICID: 1185243
Article type: Short communication
IC™ Value: 6.00
Abstract provided by Publisher
 
In total, 1095 Mycobacterium tuberculosis clinical isolates from 282 patients with drug-resistant and 813 with drug-sensitive tuberculosis (TB) in Poland during 2007–2011 were analysed. Seventy-one (6.5%) of the patients were found to have strains of Beijing genotype as defined by spoligotyping. The majority of patients were Polish–born; among foreign-born a large proportion came from Asia. Analysis showed strong associations between Beijing genotype infection and MDR, pre-XDR and XDR resistance, with a considerable relative risk among new patients, suggesting that this is due to increased spread of drug-resistant strains rather than acquisition of resistance during treatment.
DOI: 10.5604/17331331.1185243
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